It's 2417, and the Planetary Union promotes Ed Mercer to Captain of the exploratory vessel The U.S.S. Orville. Ed's enthusiasm for his new position is dampened when his ex-wife, Kelly Grayson, is assigned to be his First Officer. While on their first routine mission, the Orville crew is ambushed by the Krill, a vicious alien race, who are bent on stealing a device that can cause time to accelerate.
When Ed and Kelly are tricked by a hologram of a ship in distress and find themselves prisoners in a replica of their former home, Alara must step up in her first command of the Orville and attempt a heroic rescue. Meanwhile, Bortus and Klyden receive some happy, yet unexpected news.
The Orville crew is divided between cultures when Bortus and Klyden debate if their newly born offspring should receive a controversial surgery.
Ed and the Orville crew encounter a massive vessel adrift in space, which is in danger of colliding with a star. While some of the crew set out to help the ship's inhabitants, Bortus, Gordon, and John stay behind and fend off a Krill attack on another Union ship
When two Union anthropologists go missing on a planet similar to 21st century Earth, Ed sends a team led by Kelly to find them, but the mission quickly goes awry when they realize the society’s government is completely based on a public voting system to determine punishment.
Ed and the crew set out to save Dr. Finn, her two sons and Isaac after their shuttle gets thrown into uncharted space and they crash-land on a moon that is light years from the Orville.
The Orville is called to mediate a peace treaty between two warring cultures, but tensions run even higher between Ed and Kelly when a familiar face boards the ship. Meanwhile Yaphit declares his love for Dr. Finn with surprising results.
When a fire breaks out on The Orville and a crew member dies, Alara begins to question if she is fit for her job, just as unusual and terrifying things start happening on the ship.
Kelly discovers that Lt. John Lamarr is smarter than he lets on. So, she pushes Ed to consider him for a key leadership position on the ship after The Orville gets damaged by a mysterious spatial anomaly causing harrowing effects to all things living.
Ed and Kelly consider the possibility of reforging their relationship, but Kelly soon crash-lands on a planet in another universe with Isaac and Gordon.
